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pentobarbital will lessen the extent or result of midostaurin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay clear of or Use Alternate Drug. Potent CYP3A4 inducers may perhaps lower midostaurin concentrations resulting in reduced efficacy.pentobarbital will reduce the extent or outcome of ibuprofen by impacting hepatic enzyme CYP2C9